MT-DADME-IMMA

Name	MT-DADMe-ImmA
Synonyms	MTDIA MTDIA MTDIA HCL MT-DADMe-ImmA MT-DADME-IMMA MT-DADMe-ImmA HCl MT-DADME-IMMA HCL Methylthio-DADMe-Immucillin A METHYLTHIO-DADME-IMMUCILLIN A METHYLTHIO-DADME-IMMUCILLIN A (3R,4S)-1-((4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol 3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)-
CAS	653592-04-2

Molecular Formula	C13H19N5OS
Molar Mass	293.39
Density	1.412±0.06 g/cm3(Predicted)
Melting Point	108-110 °C
Boling Point	566.1±50.0 °C(Predicted)
Solubility	DMSO
pKa	14.13±0.40(Predicted)
Storage Condition	-20℃
In vitro study	Treatment of cultured cells with MT-DADMe-ImmA and MTA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. The same treatment does not induce apoptosis in normal human fibroblast cell lines (CRL2522 and GM02037) or in MCF7, a breast cancer cell line with an MTAP gene deletion. MT-DADMe-ImmA alone does not induce apoptosis in any cell line, implicating MTA as the active agent.
In vivo study	The t 1/2 for onset of inhibition is 50 min with complete inhibition by 250 min. MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA.

Last Update：2024-01-02 23:10:35

biological activity	MT-DADMe-ImmA is an inhibitor of human 5 '-methylthioadenosine phosphorylase (MTAP) with a Ki value of 90 pM.
Target	Ki: 90 pM (MTAP)

Last Update：2024-04-10 22:30:50

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Product Name: MT-DADMe-ImmA Visit Supplier Webpage Request for quotation
CAS: 653592-04-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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MT-DADME-IMMA

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